Our Goal
The nanoSCAN project aims to transform tissue analysis with a novel 3D spatial biology platform that provides crucial insights into cellular and tissue functions.
Current limitations in spatial biology
Spatial biology visualizes the interaction of molecules with their 3D environment, which is essential for cell and tissue screening. However, most spatial biology imaging technologies, based on wide-field microscopy, have limited spatial resolution and insufficient molecular profiling. A major obstacle to quantitative tissue imaging progress is the lack of a single instrument that can cover various complementary scales from tissue to molecule with high speed, high throughput, and high accuracy.
Our innovative SAFe-nSCAN imaging platform
To address these limitations, we propose to develop a new imaging platform, the SAFe-nSCAN, which combines multi-scale optical microscopy solutions, from structured illumination microscopy for rapid cell and tissue inspection and classification to single-molecule localization microscopy techniques for deeper and higher nanoscopic 3D information over preselected regions.
The consortium consists of academic partners who will develop the technology, a non-profit association that will facilitate beta testing and promote the technology, and an SME that will collaborate with a new startup company to manufacture chips and bring molecular resolution spatial biology to the market.
Game-changing technology
nanoSCAN is a game-changing technology that provides crucial 3D spatial biology imaging insights into cellular and tissue function for personalized immune-oncology therapy.
New era of nanoscale resolution
Our platform is a breakthrough imaging technology, covering the entire resolution spectrum and employing new chip technology and a microfluidic device for multiplexed nanoscopy, increasing speed and efficiency.
SAFe-nSCAN imaging platform is highly innovative,
being the first solution to offer:
Coverage of the entire length spectrum from tissue to sub-molecule in a single instrument (mm to nm)
Imaging at multiple scales, from widefield to structured illumination to single molecule localization microscopy
