It’s time to look back on our accomplishments and milestones after the first 12 months of the nanoSCAN project!  

After kicking off our project with the first in-person meeting in Paris in November 2024, we have already seen some encouraging early results, from promising tests and experiments to our first conference presentations. In addition, we have invested significant effort in defining clear tasks, dependencies, and collaboration. This strong foundation sets the stage for an even greater focus on technical advancements in the years ahead.  

Building the SAFe-nSCAN Platform 

One of the core objectives of nanoSCAN is the development of a unique SAFe-nSCAN platform through the integration of innovative technologies from different consortium members. This interdisciplinary collaboration has been instrumental in preparing for the next project phase, which will focus on the generation of the first prototypes. 

Beyond technological progress, our partners’ efforts have set the stage for the future launch of YourChip, a spin-off company that will commercialize opto-fluidic chips. This initiative aligns with our broader goal of transitioning our breakthrough technology to the market and ensuring commercialization of the final product. 

Key milestones from year one 

The first year of nanoSCAN has been dedicated to adapting Technology Readiness Level (TRL) 4 results for integration into the initial SAFe-nSCAN prototype. Here are the key contributions from our partners: 

CNR (WP1) focused on chip development fabrication, introducing modifications to enable both two-beam and multi-beam outputs for ModLoc and Structured Illumination Microscopy (SIM) operations respectively. Optimization efforts have enhanced optical power transmission and multi-wavelength operation for ModLoc as well as multibeam operation for SIM, leading to the successful delivery of the first operating prototypes to partners. 

CNRS (WP2) simplified the ModLoc technique to facilitate its transition into a prototype. Achieved alternative optical configurations for compact and flexible demodulation of single-molecule axial positioning, along with improved spectral demixing implementation. 

ABBELIGHT (WP3, WP5, WP6) led technological developments, designed the first SAFe-nSCAN prototype, and de-risked the SIM modality. Additionally, ABBELIGHT worked on the software platform for multiscale data acquisition and analysis, conducted market research through prospect interviews, refined market needs, and planned the technology-to-market transition. 

POLIMI (WP1, WP5) optimized the chip developed by CNR, tested its performance, developed control electronics, and designed software for SIM data acquisition and reconstruction. POLIMI also built a prototype of the chip-based SIM system, which was presented at conferences and demonstrations, and participated in training activities for the spinoff establishment. 

LLE-AISBL (WP5) established the project’s branding by creating a logo and website. Additionally, LLE-AISBL developed and initiated the first Dissemination and Exploitation Plan, including communication activities. 

Advancing towards TRL5 

The first-year activities primarily focused on the project’s technical objectives, ensuring alignment with the SAFe-nSCAN prototype development. These efforts also laid the groundwork for achieving business objectives. A TRL of 5 was achieved through: 

• Research to optimize technology within individual partner laboratories 

• Close collaboration between partners to fine-tune optimization towards the SAFe-nSCAN prototype 

• IP protection initiatives 

• Market exploration and opportunity assessments 

• Training personnel in preparation for the YourChip spin-off 

Looking ahead 

As we enter the second year of nanoSCAN, we look forward to upcoming events and continued progress in revolutionizing spatial biology. Stay connected with us by subscribing to our newsletter and following us on LinkedIn and Bluesky to stay updated on our latest advancements!